来源：Anticancer Res. 2020 Feb;40(2)

题目：Prognostic Value of Age and Distant Metastasis in Differentiated Thyroid Carcinoma Undergoing Salvage Surgery.

年龄和远处转移在分化型甲状腺癌复发后再次手术中的预后价值

AIM:

To investigate the association between survival outcomes and clinicopathological factors, including pathological restaging based on the UICC8, among patients with recurrence differentiated thyroid carcinoma undergoing salvage surgery of local site.

目的：为了研究临床病理特征在分化型甲状腺癌局部复发再次手术后的生存结局。

PATIENTS AND METHODS:

A total of 54 patients who underwent salvage surgery of local site for recurrence differentiated thyroid carcinoma were enrolled. The optimal cutoff ages at salvage surgery for predicting death and cancer-specific death were determined by receiver operating curve analysis. Overall and cancer-specific survivals were determined using log-rank test and Cox's proportional hazards model.

本研究纳入54例因局部复发再次手术的分化型甲状腺癌患者。通过受试者特征曲线，确定年龄的最佳截取值对再次手术时预测死亡和癌症特异性死亡的价值。

RESULTS:

Univariate analysis showed that age and the presence of distant metastasis at salvage surgery were significantly associated with overall survival (p=0.01 and p<0.05, respectively) and cancer-specific survival (p=0.02 and p=0.01, respectively).

The optimal cutoff age at salvage surgery for predicting the detection of both death (p=0.01) and cancer-specific death (p=0.02) was 65 years. Multivariate analysis showed that age ≥65 years and the presence of distant metastasis were significantly associated with shorter overall survival (p<0.01 and p=0.03, respectively) and shorter cancer-specific survival (p<0.01 and p=0.01, respectively).

结果：单因素分析显示，年龄和再次手术时有无远处转移与总生存率(p=0.01和p<0.05)和肿瘤特异性生存率(p=0.02和p=0.01)呈显著相关性。

再次手术时预测死亡(p=0.01)和癌症特异性死亡(p=0.02)检测的最佳年龄截取值是65岁。多因素分析显示，年龄≥65岁和远处转移与总生存期(p<0.0 1和p=0.0 3)和肿瘤特异性生存期(p<0.0 1和p=0.0 1)呈显著相关性。

CONCLUSION:

Older age and the presence of distant metastasis at salvage surgery of local site were identified as predictors for poor survival outcomes in recurrence differentiated thyroid carcinoma.

结论：高龄和局部再次手术时远处转移是复发分化型甲状腺癌预后不良的预测因素。